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Centre for Arab Genomic Studies (CAGS) in Dubai (United Arab Emirates) reports Arabs suffer from one of the highest rates of genetic disease in the world. Some 906 genetic disorders have been identified in Arabs and their descendants. Several common diseases in the UAE, Oman and Bahrain have reached epidemic levels - more than 100 cases per 100,000. They include thalassaemia (a blood disorder), diabetes, breast cancer and Down's syndrome. Some of the disorders have reached epic proportions like sickle cell disorder, heart diseases, alpha-thalassemia, diabetes mellitus. Some of the main genetic diseases prevalent in the Arab countries are hemoglobin disorders, birth defects, inherited metabolic diseases and neurogenetic disorders. hemoglobin disorders are sickle cell disease and thalassemia and g6. Multiple pterygium syndrome, Down syndrome, microcephaly and Bardet-Biedl syndrome are examples of the disorders causing birth defects. Arab countries have the highest prevalence of birth defects in the world of neurogenetic disorders are Tourette's syndrome, Wilson's disease, Charcot-Marie-Tooth disease, mitochondrial encephalomyopathies and Niemann-Pick disease.〔(【引用サイトリンク】title=Arabs bear brunt of Genetic Disorders )〕 ==Genetic diseases Databases in Arabic countries and studies== Several organizations maintain databases for each Arabic country. CAGS is the main organization based in UAE. CAGS or the Centre for Arab Genomic Studies initiated a pilot project to construct the "Catalogue for Transmission Genetics in Arabs" (CTGA) database for genetic disorders in Arab populations. At present, the CTGA database, centrally maintained in Dubai, hosts entries for nearly 1540 Mendelian disorders and related genes and this number is increasing as researchers are joining the largest Arab scientific effort to define genetic disorders described in the region. The Center promote research studies on these emergent disorders. Some of the challenges are: Hemoglobinopathy, sickle cell anemia, glucose-6-phosphate dehydrogenase deficiency, and fragile X syndrome (FXS) which is an inherited genetic condition with critical consequences. The Centre provide information about specific countries, and maintain a list of Genomic diseases.〔(【引用サイトリンク】title=Genetic Disorders in Arab Populations )〕 Specific rare autosomal recessive diseases are high in Arabic countries like Bardet Biedl syndrome, Meckel syndrome, congenital chloride diarrhea, severe childhood autosomal recessive muscular dystrophy (SMARMD) Lysosomal storage diseases and PKU are high in the Gulf states. Dr Teebi's book provides detailed information and by country. Even the Middle East respiratory syndrome coronavirus (MERS-CoV) that was first identified in Saudi Arabia last year, it has infected 77 people, mostly in the Middle East and Europe. Forty of them - more than half - have died. But MERS is not yet a pandemic, could become pervasive in genetic disease patient. Dr Thurman' guidebook about Rare genetic diseases another book Arabic genetic disorders layman guide Suadi Journal article about genetic diseases in Arabic countries The highest proportion of genetic disorders manifestations are: congenital malformations followed by endocrine metabolic disorders and then by Neuron disorders (such as Neuromotor disease)and then by blood immune disorders and then neoplasms. The Mode of Inheritance is mainly autosomal recessive followed by autosomal dominant. Some of the diseases are beta-thalassemia mutations, sickle-cell disease, congenital heart-disease, glucose-6-phosphate dehydrogenase deficiency, alpha-thalassemia, molecular characterization, recessive osteoperosis, gluthanione-reducatsafe DEf. A study about sickle cell anemia in Arabs article about Birth defects 6Glucose Phisphate isomere deficiency responsible for unexpected hemolytic episodes. one of late Dr Teebi's syndromes. flash cards guide. 〔(【引用サイトリンク】title=Genetic diseases studies on Arabic world )〕〔(【引用サイトリンク】title=Genetic Disorders in Arabs )〕〔(【引用サイトリンク】title=Genetic Diseases Studies in Arabic Countries )〕〔(【引用サイトリンク】title=Arab Information Center for Genetic Counseling )〕 NY times article In Palestinian Arabs study study about potential on pharmacology another study on Arab Palestinians Database of Genetic disorders in Arabs study In Palestinians new general study about databases Database for B thalassemia in Arabs Israeli National genetic bank contains genetic mutations of Arabs Teebi database 2002 2010 genes responsible for genetic diseases among Palestinian Arabs The next Pan-Arab conference Nov 2013 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Genetic studies on Arabs」の詳細全文を読む スポンサード リンク
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